Jephte Akakpo, Ph.D., University of Kansas Medical Center
By Frontiers , Clinical and Translational Science Institute
Aug 30, 2024
Jephte Akakpo, Ph.D., University of Kansas Medical Center
Mechanism of Acetaminophen-Induced Nephrotoxicity
Jephte Akakpo, Ph.D. from the University of Kansas Medical Center Kansas City, particpated as a scholar in the TL1 Postdoctoral program. His research project titled "Mechanism of Acetaminophen-Induced Nephrotoxicity" was conducted in the Pharmacology Toxicology and Therapeutics Department under the guidance of Hartmut Jaeschke, Ph.D., ATS, FAASLD. This project commenced on July 1, 2022, and concluded on June 30, 2024.
In his postdoctoral TL1 project, Akakpo concentrated on advancing his skills as a toxicologist while aiming to become an independent researcher in the biomedical sciences. His research focused on elucidating the molecular and cell signaling mechanisms underlying acetaminophen-induced nephrotoxicity and evaluating whether fomepizole's protective effects on the kidney are independent of its effects on the liver, using mouse models and primary human kidney cells. Notable milestones included significant progress in understanding these mechanisms and assessing fomepizole's efficacy in preventing multi-organ system failure.
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