Funding Opportunities

Integrating Special Populations Pilot Award

Integrating Special Populations (ISP) Pilot Program provides grant funding and other support for clinical and translational research across a broad range of scientific disciplines. The objective of this pilot program is to support new and innovative ideas that will lead to externally funded awards. The Frontiers ISP Pilot Award addresses this goal by providing funds to help investigators carry out early-stage research addressing our primary aims 1. Improve health outcomes across the lifespan through multidisciplinary, multi-organizational teams that include patients, caregivers, clinicians, scientists, and other stakeholders and 2. Improve rare disease health outcomes by leveraging input from all stakeholders in study design.

One award is given annually for $25,000.

ISP Research Focus Areas

• Consequences of Maternal-Fetal-Child, and Adolescent disorders and disparities on the health of adults and older adults.
• Supporting Transitions of Care from childhood to young adult and adult to older adult.
• Incorporating participants who are older adults or rural residents in drug and other intervention development and testing.
• Addressing unique challenges of rare diseases and improving access to care and other resources for families in rural and underserved communities.

Application Materials

Applications are not currently being accepted.

The Broderick Crawford Community Partnership Awards

The Broderick Crawford Community Partnership Award (BCCPA) supports the development of new community-academic partnerships. These awards will be used to facilitate community-based activities that build trust and strengthen relationships between researchers, patient advocates, community members/community-based organizations and researchers.

Thank you for your interest in the Broderick Crawford Community Partnership Award. The request for applications has closed. Applicants will be notified by October 23, 2026.

Up to six awards issued annually; each award is up to $2,500. 

About Broderick A. Crawford:

Broderick Crawford was the President and Executive Director of the NBC Community Development Corporation. With over 30 years of experience in health care and community advocacy, Crawford was a national leader for community voice in research. He served on the Recruitment Innovation Center Community Advisory Board and was a Co-Principal Investigator on a large National Institutes of Health funded RADx-UP grant project in 10 Kansas counties. Many of us were fortunate enough to call him a friend and colleague and he more than deserves this award to be named in his honor.

Consortium of Rural States (CORES) Multi-Institutional Pilot Program

Innovating Together. Transforming Rural Health.
Backed by the National Center for Advancing Translational Sciences’ (NCATS) Clinical & Translational Science Award (CTSA) program, the Consortium of Rural States (CORES)—representing CTSA hubs at the University of Utah Health, University of New Mexico Health Sciences Center/University of Arizona (SW Cacti), Frontiers CTSI, University of Kentucky, University of Arkansas for Medical Sciences, University of Iowa, Dartmouth College/Dartmouth-Hitchcock, Medical University of South Carolina, and Penn State University—is thrilled to launch a new, dynamic pilot process designed to spark collaborative translational science across our multi institutional network. This initiative accelerates the
development, testing, and implementation of innovative solutions to improve health outcomes, while building strong collaborative pathways across CORES to drive meaningful care model transformation in rural communities and position these efforts for national scaling through external funding.

A Fresh, Phased Pilot Model – Calling Investigators
This year, CORES is introducing an innovative, teambuilding–first approach to project development. In Phase 1, interested investigators apply to join cross-institutional teams organized around shared translational challenges specific to our focus areas (see below). In Phase 2, the assembled teams collaborate to develop their projects, refining questions and co-creating proposals designed for real-world impact in rural settings. Finally, in Phase 3, funded projects are executed; teams work together to put their plans into action with ongoing support from the CORES consortium.

Focus Areas
Data & Technology Infrastructure for Rural Health
Harnessing AI, remote monitoring, data integration, and real-world data pipelines to create scalable, tech enabled solutions that improve health outcomes across rural environments.
Chronic Disease Prevention, Diagnosis & Management
Emphasizing partnerships with Practice-Based Research Networks (PBRNs) and clear translational and implementation strategies to improve chronic disease care in rural communities.
Maternal & Infant Health
Innovative approaches to overcoming barriers in access to maternal and infant care, with an emphasis on improving outcomes for rural populations.

Applications are not currently being accepted.

Pilot Award Frequently Asked Questions (FAQ)

Implementation Science (IS) Pilot Program

The Implementation Science (IS) Pilot Program is a collaboration with Frontiers Implementation and Measurement for Program Assessment, Change and Translation (IMPACT) team. The IS Pilot Program’s goal is to support implementation science studies that address barriers to the adoption, adaptation, integration and/or sustainability of evidence-based guidelines, interventions, tools, policies or other innovations. This funding opportunity is designed to support implementation science that addresses questions on how to move proven approaches into practice across a variety of settings. We expect these projects to generate preliminary data that investigators will use for subsequent extramural funding applications.

Request for Applications (RFA)

Introduction

The National Center for Advancing Translational Sciences’ (NCATS) mission is to turn biomedical research discoveries into health solutions, including diagnostics, treatments, and interventions, through the application of translational science. Their vision is “More treatments for all people more quickly”. The NCATS Clinical and Translational Science Award (CTSA) Program, supports translational research and science through fostering collaborations among academic institutions that will improve the efficiency, quality and impact of the process for improving human health.

Translational Science Requirement

Pilot projects are required to focus on translational science, i.e., understanding a scientific or operational principle underlying a step of the translational process with the goal of developing generalizable principles to accelerate translational research. Applicants are required to address at least one of the principles but should include all relevant principles.

Implementation Science

Projects must propose innovative research to understand the implementation context, enhance implementation measures and methods, and improve the implementation process.

Examples of relevant Implementation Science studies that may be supported:

• Testing or tailoring of dissemination and implementation strategies to enhance adoption of evidence-based interventions
• Examining the scale-up, sustainability, or spread of effective interventions
• Improving methods or measures for implementation outcomes
• Development or refinement of implementation tools (e.g., decision-support, audit-and-feedback reports, workflow integration aids)
• Qualitative or mixed-methods studies to identify barriers and facilitators to implementation
• Adaptation of evidence-based interventions for new populations, settings, or delivery models
• Studies designed to de-implement or reduce the use of practices that lack evidence, were adopted prematurely, provide minimal benefit, or are potentially harmful or wasteful

Lauren S. Aaronson Clinical and Translational Science Pilot Program

The Lauren S. Aaronson Clinical and Translational Science (CTS) Pilot Program provides educational opportunities and resources during application development and project implementation, proposal review, research funding, and support to cultivate multidisciplinary, investigator-initiated CTS projects. The Frontiers CTS Pilot Program advances original, promising investigation addressing translational science questions, promoting subsequent externally funded high-impact research, with the objective of developing generalizable solutions to accelerate CTS innovation to benefit human health. Translational science seeks to develop, demonstrate, and disseminate generalizable innovations and strategies to improve the process of translational research.

The Pilot Program goal is to accelerate high quality, innovative CTS through infrastructure and funding support for pilot research projects that generate preliminary data for subsequent extramural funding applications. The Frontiers CTS Pilot Program will promote advances in CTS by supporting early- and mid-career investigators through one-year pilot funding. Pilot projects will demonstrate highly significant, collaborative projects that address key challenges in CTS with high potential for future external funding.

Up to four awards are issued annually for up to $50,000 each. 

Full request for applications.

The National Center for Advancing Translational Sciences’ (NCATS) mission is to turn biomedical research discoveries into health solutions, including diagnostics, treatments, and interventions, through the application of translational science. Their vision is “More treatments for all people more quickly”. The NCATS Clinical and Translational Science Award (CTSA) Program supports translational research and science through fostering collaborations among academic institutions that will improve the efficiency, quality and impact of the process for improving human health.

Translational Science and Translational Research: Complementary Concepts:

Key Definitions from NCATS:

• Translation is “the process of turning laboratory, clinic, and community observations into health-improving interventions like diagnostics, therapeutics and behavioral changes”.
• Translational research focuses on advancing a step of the translational process for a specific target/disease.
• Translational science seeks to develop, demonstrate, and disseminate generalizable innovations and strategies to improve the process of translational research. These terms are not mutually exclusive in many cases.

Translational science projects seek to 1. identify and understand barriers that delay progress or limit the quality or impact of translational research (e.g., clinical trial recruitment, data interoperability, implementation, etc.), and 2. develop innovative solutions (e.g., methods, best practices, tools, technologies) to overcome these barriers. Addressing critical barriers will allow subsequent translational research to accelerate the time from discovery to improved human health. The innovative solutions will have broad applicability to multiple research projects, increasing capacity and efficiency.

Pilot projects are required to include a focus on translational science, i.e., understanding a scientific or operational principle underlying a step of the translational process with the goal of developing generalizable principles to accelerate translational research. Applicants are required to address at least one of the principles but should include all relevant principles. For this funding program it is likely, and acceptable, for applicants to include both translational research and translational science in their proposal.

Pilot Award Program has identified the following areas for Programmatic Fit.

• Studies that include multidisciplinary perspectives.
• Studies that address health issues among local populations, including rural communities.
• Community-based research involving participants/patients, families, caregivers and/or communities, which test new treatments, interventions, recruitment/retention strategies, or policies that impact health outcomes.
• Implementation and dissemination studies, effectiveness, and/or dissemination of clinical research findings into practice.

Examples of activities that may be supported:

• Development of new research methodology and/or new technologies/tools/resources that will advance CTS and thus increase the efficiency and effectiveness of translation.
• Early-stage development of new therapy/technology with generalizable application to an identified translational roadblock.
• Demonstration in a particular use case(s) that the new methodology or technology advances translational science by successfully making one or more steps of the translational process more effective or efficient.
• Dissemination of effective tools, methods, processes, and training paradigms.
• Feasibility/proof of concept studies to support future CTS projects.

Please make sure to review the National Institutes of Health's current priorities. 

Institute for Advancing Medical Innovation Trailblazer Awards

The Institute for Advancing Medical Innovation (IAMI) Trailblazer Award provides grant funding and other support for clinical and translational research across a broad range of scientific disciplines. The objective of this pilot program is to support new and innovative ideas that will lead to externally funded awards. The Frontiers IAMI Trailblazer Award addresses this goal by providing funds to help investigators carry out early-stage project development of novel drugs, devices, and diagnostics. The overall intent is to acquire research results that are disseminated in impactful publications, support successful extramural funding applications, and yield products to be entered into our product development pipeline.

IAMI Research Focus Areas

Experimental Therapeutics Trials

Eligible research activities include a) clinical validation of a drug target; b) clinical pharmacology (e.g., drug metabolism, bioanalysis, pharmacokinetics, pharmacodynamics, pharmacogenomics, allometric scaling); c) clinical proof of concept of a novel therapeutic or a repurposed FDA-approved or abandoned drug. Eligible awardees must have demonstrated proof of principle in validated in vitro and/or in vivo preclinical models.

Drug and Medical Device Development

Eligible research activity includes high throughput screening; generation and optimization of small molecule lead candidates; discovery of macromolecule therapeutics; synthesis of sufficient quantities of active pharmaceutical ingredient required for animal testing; conduct of preclinical safety, pharmacokinetic and proof of principle studies in validated animal models of disease; formulation development (including analytical chemistry support); as well as creation of prototype medical devices as well as necessary device testing.

Biomarker Discovery and Validation

Eligible research activities include a) biospecimen collection; b) patient registry development; c) genetic, genomic, proteomic and metabolomic analysis of patient specimens, and d) analysis of patient specimens using established and investigational methods to discover and validate biomarkers of drug activity.

Entrepreneurship Activities Consistent with IAMI’s Mission

Eligible research activities defining the investment thesis for potential product development opportunities, including unmet medical need, proposed solution, market, competitive landscape, patent position and strategy, summary of existing data, product development and regulatory planning, marketing and licensing strategy, as well as support for obtaining key opinion leader input.

While not required, special consideration will be given to applications which address the CTSA priority of research into the needs of the rare disease community.

Biostatistics, Epidemiology and Research Design Trailblazer Award

The Biostatistics, Epidemiology, and Research Design (BERD) Trailblazer Award provides grant funding to support statistical, epidemiological, and data science investigations toward novel methods development that will improve clinical and translational research (CTR) inferences. BERD Trailblazer Awards support research projects for methods development for CTR. 

One award is given annually for up to $20,000. 

BERD Research Focus Areas

Frontiers BERD Trailblazer Awards support projects that address methodologies or analyses useful to the study of all diseases, and include academic disciplines such as biostatistics, epidemiology, bioinformatics, data science, and other quantitative areas that impact clinical and translational science.

Application Materials

Applications are not currently being accepted.

Biostatistics, Epidemiology and Research Design (BERD) Vouchers

Vouchers ($40,000 total per year, up to $5,000 per voucher): Open to any researcher from Frontiers partner institutions to support biostatistical assistance may apply for a voucher to pay for the cost of study design, data analysis, and bioinformatics. Contact the BERD navigator for details. The CTSI will follow up with each PI within 1 year after voucher approval with respect to publications, abstracts, or grant submissions related to the funded project.

Learn about previous projects that BERD vouchers have supported!