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Institute of Advancing Medical Innovation Awardee: Hao Lou, Ph.D., University of Kansas

By Frontiers , Clinical and Translational Science Institute

Mar 09, 2026

Project Title: Developing irisin mutants and fusion proteins to combat obesity

It’s no secret that obesity is prevalent in our society. With this comes the need for therapeutics to promote weight loss and reduce incidence of obesity-related health concerns. With his Institute for Advancing Medical Innovation (IAMI) Trailblazer Award, Hao Lou, Ph.D., is in the process of developing a novel therapeutic to increase calorie expenditure through adipose tissue. Lou’s program of research focuses on subcutaneous (under the skin) drug delivery and diseases related to subcutaneous tissues. The overarching idea is simple: modify white adipose tissue (bad fat tissue used to store energy) into brown adipose tissue (good fat tissue used for burning energy).

Irisin, a hormone secreted by muscles, is a promising candidate for this. Irisin turns white adipose tissue into brown adipose tissues, and as such, may help increase energy use and burn calories to mitigate obesity and related issues. Lou will derive and purify irisin from e. coli and develop various formulations to test in a novel device. One formulation will be a hydrogel which can be used to maintain prolonged action on subcutaneous sites. The other will be a freeze-dried or lifeless formulation to prolong shelf life. As a therapeutic, irisin would not rely on inducing feelings of satiety to reduce caloric intake; instead, it would increase the potential for energy use and burning calories, which could be used in combination with other weight-loss strategies.

Along with a multidisciplinary research team, Lou is developing a novel method of testing drug delivery and efficacy before introducing the compound into animals or humans. To do so, Lou, who is an assistant professor in the Department of Pharmaceutical Chemistry at the University of Kansas, is incorporating his extensive experience in drug formulation development and his background in engineering. He is utilizing 3D printing to create an in vitro device that will mimic in vivo subcutaneous tissues and allow him and other researchers to evaluate the temporal performance of the drug in order to predict how the drug will work in vivo. This approach has the potential to shorten drug development timelines, especially during pre-clinical and clinical phases.  All told, Lou’s project will help address the ongoing obesity epidemic by developing a novel compound and method for testing efficacy.
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