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Reproducibility Rounds How Reproducible is Health Science Research?

Abstract: We will discuss the methods, results, and implications of a series of scoping and systematic reviews that synthesized evidence on the reproducibility of health science research. Specific aims of the projects included describing and categorizing methods and metrics used to quantify reproducibility, synthesizing estimates of the prevalence of reproducible research, and characterizing factors associated with reproducibility. We will describe our dataset of 1,340 articles with a focus on the sub-set with empirical data. We will report on the seven methods used for conducting reproducibility research, 38 metrics to quantify reproducibility, 180 estimates of the prevalence of reproducibility, and 234 factors associated with reproducibility which we grouped into modifiable and nonmodifiable categories. Finally, we will discuss the significant heterogeneity in the evidence and challenges in synthesizing this data.

Reproducibility Rounds, produced in collaboration with representatives from multiple CTSA hubs, is a bimonthly webinar, designed to foster an exchange of experiences and ideas between institutions, researchers and other stakeholders about how to improve biomedical research rigor and reproducibility. Rounds will be interactive. Future sessions and recordings of past rounds can be found on the SPORR website. Interested in contributing? Contact us at sporr@stanford.edu. SPORR is part of Spectrum, Stanford’s Center for Clinical and Translational Research and Education, supported by the National Center for Advancing Translational Sciences of the NIH, under Award Numbers UL1TR003142 and UM1TR004921. SPORR is also supported by the Stanford School of Medicine Research Office.